NSAIDs increase risk of miscarriage
A study from Quebec, comparing the records of 5,000 women who miscarried with the medical records of 50,000 women who experienced a pregnancy but did not miscarry, demonstrated that women taking NSAIDs during the first 20 weeks of pregnancy increase the risk of miscarriage by 2.64 times. It is believed that NSAIDs may interfere with levels of prostaglandin hormones that are involved in inducing labor. Therisk was greatest for diclofenac, and higher for naproxen (Aleve) than for ibuprofen. The author recommended acetaminophen as a safe alternativefor use early in pregnancy.